Search results for "collagen proportionate area"

showing 2 items of 2 documents

Computer-assisted image analysis of liver collagen: relationship to Ishak scoring and hepatic venous pressure gradient.

2009

Histopathological scoring of disease stage uses descriptive categories without measuring the amount of fibrosis. Collagen, the major component of fibrous tissue, can be quantified by computer-assisted digital image analysis (DIA) using histological sections. We determined relationships between DIA, Ishak stage, and hepatic venous pressure gradient (HVPG) reflecting severity of fibrosis. One hundred fifteen patients with hepatitis C virus (HCV) who had undergone transplantation had 250 consecutive transjugular liver biopsies combined with HVPG (median length, 22 mm; median total portal tracts, 12), evaluated using the Ishak system and stained with Sirus red for DIA. Liver collagen was expres…

AdultLiver CirrhosisMalemedicine.medical_specialtyCirrhosismedicine.medical_treatmentPortal venous pressureImage ProcessingBiopsyLiver transplantationHepatic VeinsGastroenterologyComputer-AssistedInternal medicineBiopsymedicineImage Processing Computer-AssistedHumansProspective StudiesAgedHepatologymedicine.diagnostic_testbusiness.industryHepatologyMiddle Agedmedicine.diseaseHepatitis CConfidence intervalSurgeryLiver TransplantationTransplantationLogistic ModelsLiverAdult; Aged; Biopsy; Collagen; Female; Hepatic Veins; Hepatitis C; Humans; Liver; Liver Cirrhosis; Liver Transplantation; Logistic Models; Male; Middle Aged; Prospective Studies; Venous Pressure; Image Processing Computer-AssistedFemaleCollagenTransient elastographybusinessVenous Pressurecollagen proportionate area HVPG liver fibrosisHepatology (Baltimore, Md.)
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The relationship between transient elastography and histological collagen proportionate area for assessing fibrosis in chronic viral hepatitis

2012

Collagen proportionate area (CPA) has a better correlation with hepatic venous pressure gradient (HVPG) than with Ishak stage. Liver stiffness measurement (LSM) is proposed as non invasive marker of portal hypertension/disease progression. Our aim was to compare LSM and CPA with Ishak staging in chronic viral hepatitis, and HVPG in HCV hepatitis after transplantation. One hundred and sixty-nine consecutive patients with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections pre/post liver transplantation (LT), had a liver biopsy combined with LSM (transient elastography), CPA (biopsies stained with Sirius Red and evaluated by digital image analysis and expressed as CPA) and H…

AdultLiver CirrhosisMalemedicine.medical_specialtyCirrhosisHepatitis C virusmedicine.medical_treatmentBiopsyLiver transplantationmedicine.disease_causeGastroenterologyYoung AdultHepatitis B ChronicInternal medicinemedicineImage Processing Computer-AssistedHumansheterocyclic compoundsAgedtransient elastography histological collagen proportionate area fibrosis chronic viral hepatitis.medicine.diagnostic_testbusiness.industryfibrosisGastroenterologyHepatologyHepatitis C ChronicMiddle Agedmedicine.diseasetransient elastographychronic viral hepatitisLiver TransplantationTransplantationhistological collagen proportionate areaLiver biopsyMultivariate Analysiscardiovascular systemDisease ProgressionElasticity Imaging TechniquesRegression AnalysisFemaleCollagenTransient elastographyViral hepatitisbusiness
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